We are always looking for team members who share our vision of using information in a quantitative way to develop therapies that defeat disease. We are obsessed with learning and we have a passion to participate in the growth of our scientific disciplines. We believe that as we learn and grow, we are responsible to share openly with the community.

Our Mission: At Metrum Research Group, we are driven to improve health and defeat disease, particularly where there are unmet needs. We provide innovative solutions at the intersection of data, science, and technology to generate key insights that impact biomedical decision-making.

If you share our passions, we would love to hear from you!

Metrum Research Group offers a competitive salary and an excellent benefits package.

MetrumRG is seeking a talented PKPD Modeling and Simulation Scientist with a minimum of 3 years of experience to join our team. We know that the key to our company’s success is the happiness and well-being of our team. Our goal is to provide a work-life that is engaging, rewarding, and fun.

Qualified individuals will contribute to fighting diseases through strategic collaborations with our customers in biomedical research, development, and post-marketing programs for new drugs, biologics, devices, and diagnostics. M&S scientists will be expected to develop and implement quantitative, data-driven pharmacometric strategies for knowledge integration and decision-making to guide customer drug development programs. Scientists will also contribute to internal and external reporting and publication of results and will be expected to continue to develop skills and knowledge in biomedical modeling and simulation.


  • Lead interactions with biomedical industry collaborators
  • Develop strategies and conduct modeling and simulation to support biomedical decision making
  • Develop population pharmacokinetic (PK), pharmacodynamic (PD), exposure-response, disease progression, and/or systems pharmacology models
  • Apply models to support decision-making through Monte-Carlo simulation
  • Perform model-based meta-analysis of therapeutic area summary-level data
  • Perform quality control of modeling and simulation analyses
  • Prepare technical reports, manuscripts, and presentations

Requirements and Skills

  • Required: Strong proficiency with a scriptable modeling and simulation language (e.g. R, MatLab, Python)
  • Desirable: Advanced expertise with domain-specific modeling software (e.g. NONMEM, ADAPT, Monolix) and Bayesian modeling software (e.g. Stan, JAGS, OpenBUGS)
  • Desirable: Experience with Shiny, Markdown, LaTeX, unix/Linux, subversion, git
  • Desirable: A strong understanding of statistical analysis of longitudinal, landmark and repeated-measures, continuous or categorical data, within a multi-level hierarchy

Education and Experience

  • Required: M.S. or Ph.D. Degree in Mathematics, Statistics, Pharmacometrics, Pharmacokinetics, Bioinformatics, Chemical or Biomedical Engineering, or related quantitative field
  • Required: Minimum three-year experience PKPD modeling and simulation, post-graduate degree
  • Desirable: Direct experience with quantitative analytics in biomedical applications
  • Desirable: Basic understanding of drug, biologic, device, or diagnostic research and development process

Physical Demands

The job frequently requires working at a computer terminal, standing or sitting, and the ability to operate a computer with proficiency.

Work Environment

The work environment is quiet with no adverse conditions.

Metrum Research Group participates in E-verify.

Metrum Research Group is an equal-opportunity employer